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Related Experiment Videos

Verapamil in bipolar illness.

L Solomon, P Williamson

    Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Two bipolar disorder cases unresponsive to lithium were successfully treated with verapamil for hypomania and trazodone for depression. This study explores alternative treatments for bipolar disorder when lithium is not an option.

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    Area of Science:

    • Psychiatry
    • Pharmacology

    Background:

    • Lithium is a common treatment for Bipolar Affective Disorder.
    • Hyperparathyroidism and noncompliance can limit lithium use.

    Observation:

    • Two patients with Bipolar Affective Disorder previously responsive to lithium could no longer use it.
    • Verapamil effectively controlled hypomanic symptoms in both cases.

    Findings:

    • Hypomania was managed with Verapamil, a calcium channel blocker.
    • Depressive symptoms required the addition of Trazodone for effective treatment.
    • The combination therapy demonstrated efficacy in managing complex bipolar disorder cases.

    Implications:

    • Verapamil presents a viable alternative for managing hypomania in bipolar disorder when lithium is contraindicated.

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  • Combination therapy with Trazodone may be effective for treating depressive episodes in such cases.
  • Further research into calcium channel blockers for bipolar disorder is warranted.