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Predictive value of systemic inflammatory response index (SIRI) for complex coronary artery disease occurrence in

Tomasz Urbanowicz1, Michał Michalak2, Anna Komosa3

  • 1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznan, Poland. tomasz.urbanowicz@skpp.edu.pl.

Cardiology Journal
|June 14, 2023
PubMed

Insights

The systemic inflammatory response index (SIRI), a simple blood test, can help predict coronary artery disease (CAD) in patients with angina symptoms. A SIRI above 1.22 indicates a higher likelihood of significant coronary artery disease.

Area of Science:

  • Cardiology
  • Hematology
  • Inflammation Research

Background:

  • Atherosclerotic cardiovascular disease is a leading global cause of mortality.
  • Inflammatory processes are key drivers in the development and progression of coronary plaques.
  • Hematological indexes, such as the Systemic Inflammatory Response Index (SIRI), offer potential markers for inflammation.

Purpose of the Study:

  • To evaluate the predictive role of the Systemic Inflammatory Response Index (SIRI) in the occurrence of coronary artery disease (CAD).
  • To assess the utility of SIRI as a diagnostic marker in patients presenting with angina-equivalent symptoms.

Main Methods:

  • A retrospective analysis of 256 patients (174 men, 82 women) with angina-equivalent symptoms.
  • Development of a predictive model for CAD using demographic data and blood cell parameters.
  • Logistic regression multivariable analysis to identify significant predictors.

Main Results:

  • Male gender, age, body mass index, and smoking were significant demographic predictors of CAD.
  • The Systemic Inflammatory Response Index (SIRI) and red blood cell distribution width (RDW) emerged as significant laboratory predictors.
  • SIRI demonstrated a significant odds ratio (OR: 5.52) for predicting CAD.

Conclusions:

  • The Systemic Inflammatory Response Index (SIRI) is a valuable hematological index for diagnosing CAD in patients with angina-equivalent symptoms.
  • A SIRI threshold of 1.22 was associated with a higher probability of single and complex coronary artery disease (AUC: 0.725, p < 0.001).
Abstract

Keywords:
angiographycoronary artery diseasesystemic inflammatory response index (SIRI)

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