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Updated: Jul 26, 2025

Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Comparison of Translocator Protein Expression Between Tumefactive Multiple Sclerosis and Glioblastoma
Per Jensen, Morten Blinkenberg1, Lars Hageman Pinborg
1MS Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Abstract:
This figure presents a comparison of molecular imaging of the translocator protein (TSPO) and contrast-enhanced MRI in 2 patients with tumefactive multiple sclerosis and glioblastoma, respectively. In the case of the tumefactive multiple sclerosis patient, TSPO uptake is primarily located centrally, while in the glioblastoma patient, TSPO uptake is predominantly situated peripherally to the central necrotic area. These findings suggest that TSPO imaging could be a noninvasive imaging technique for distinguishing between these 2 diagnoses.

