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[Asthenia, mental fatigue and cognitive dysfunction].
N V Titova1,2, Yu N Bezdolny3, E A Katunina1,2
1Federal Center of Brain and Neurotechnologies, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 14, 2023
Summary
Asthenia, characterized by fatigue and reduced productivity, requires distinguishing between primary asthenia and chronic fatigue syndrome (CFS). This review explores the neurocognitive basis of pathological fatigue and suggests combination therapy for asthenic conditions with cognitive dysfunction.
Area of Science:
- Neuroscience
- Pathophysiology
- Clinical Medicine
Context:
- Asthenia presents with fatigue, impacting daily life and productivity.
- Distinguishing idiopathic chronic fatigue from chronic fatigue syndrome (CFS) is crucial in clinical practice.
- Fatigue can manifest as neuromuscular, cognitive, or mental fatigue.
Purpose:
- To explore the neuroanatomical and neurocognitive underpinnings of pathological fatigue.
- To examine the links between mental stress, fatigue, and cognitive impairments like subjective cognitive impairment (SCI) and mild cognitive impairment (MCI).
- To propose a rationale for combination therapy in asthenic conditions with cognitive dysfunction.
Summary:
- The article delves into the neurocognitive theory of pathological fatigue.
- It discusses the relationship between mental stress, fatigue, and cognitive impairments (SCI, MCI).
- A combination therapy involving fonturacetam and a preparation with nicotinoyl-GABA and Ginkgo Biloba is proposed for asthenia with cognitive dysfunction.
Impact:
- Provides insights into the neurobiological basis of pathological fatigue.
- Highlights the connection between mental stress and cognitive deficits in asthenia.
- Suggests a targeted therapeutic approach for managing complex asthenic conditions with cognitive impairment.
Keywords:
Ginkgo Bilobaastheniachronic fatigue syndromecognitive impairmentfatiguefonturacetammental fatiguenicotinoyl-GABAMore Related Videos
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