Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular and bioinformatic mechanism of asiaticoside on macrophage-mediated keloid pathogenesis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026

Same author

Early prediction of immune checkpoint inhibitor-related pneumonitis in advanced non-small cell lung cancer based on primary tumor delta-radiomics features.

Frontiers in immunology·2026

Same author

Identification of QTLs Associated with Stem Breaking Strength and Development of InDel Markers in Soybean Using BSA-Seq.

Plants (Basel, Switzerland)·2026

Same author

Atomic Interfacial <i>N</i>-Bridging Locks <i>Z</i>-Scheme Charge Transfer in CsPbBr<sub>3</sub>@UiO-66-NH<sub>2</sub> Heterojunctions.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

Discovery of a novel cinnamoyl piperazinyl alepterolic acid hybrid as a TrxR1 inhibitor for inducing ROS/ER stress-mediated apoptosis in breast cancer.

European journal of medicinal chemistry·2026

Same author

In Vivo Metabolic Profiling of Equisetum debile Roxb. in Rats Based on High-Resolution Mass Spectrometry.

Biomedical chromatography : BMC·2026

Search research articles

Related Experiment Video

Updated: Jul 17, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

White Matter Functional Dysregulation in Amyotrophic Lateral Sclerosis: Machine Learning-Based Biomarkers and

Haifeng Chen^1,2,3,4, Zhiyuan Yang^1,2,3,4, Hailan Meng^1,2,3,4

¹Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Current Neuropharmacology

|July 16, 2026

Summary

Amyotrophic lateral sclerosis (ALS) involves distinct white matter (WM) functional changes, identified using MRI and machine learning. These WM biomarkers may aid in diagnosing ALS and monitoring disease progression.

Keywords:

Amyotrophic lateral sclerosis imaging transcriptomics neuro-transmission resting-state magnetic resonance imaging white matter functional networks

More Related Videos

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jul 17, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

Published on: December 15, 2023

Area of Science:

Neuroscience
Neuroimaging
Biomarkers

Background:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting motor neurons.
The functional pathophysiology of white matter (WM) in ALS remains poorly understood.

Purpose of the Study:

To investigate WM functional abnormalities in ALS patients using resting-state functional MRI.
To evaluate the diagnostic and prognostic utility of WM functional patterns in ALS.
To explore the molecular and genetic underpinnings of WM dysfunction in ALS.

Main Methods:

Resting-state functional MRI was employed in 50 ALS patients and 55 healthy controls.
Machine learning, including support vector machine (SVM), was used for classification and prediction.
Neurotransmitter mapping and imaging transcriptomics were utilized to explore pathophysiological mechanisms.

Main Results:

ALS patients showed reduced central WM activity (e.g., corticospinal tracts) and elevated anterior/posterior WM activity.
Aberrant topological properties and disrupted functional connectivity were observed in bilateral precentral/postcentral WM networks.
An SVM model achieved 75.24% accuracy in classifying ALS and predicted disease progression (r = 0.56, p = 0.001).

Conclusions:

Distinct patterns of WM functional dysfunction are present in ALS.
These WM alterations are linked to neurotransmitter distribution and gene expression profiles.
WM-centric biomarkers offer potential for developing therapeutic monitoring strategies in ALS.