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Clinical efficacy of remdesivir for COVID-19 in children: A propensity-score-matched analysis

Kensuke Shoji1, Yusuke Asai2, Takayuki Akiyama3

  • 1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|June 14, 2023
PubMed

Insights

The clinical efficacy of remdesivir for pediatric COVID-19 patients remains uncertain. While more children receiving remdesivir saw fever reduction by Day 4, the difference was not statistically significant compared to those not given the antiviral.

Area of Science:

  • Pediatric Infectious Diseases
  • Viral Respiratory Illnesses
  • Pharmacological Interventions

Background:

  • The clinical effectiveness of remdesivir in pediatric patients diagnosed with COVID-19 is not well-established.
  • Further research is needed to understand the benefits of antiviral treatments in children.

Purpose of the Study:

  • To evaluate the clinical efficacy of remdesivir in children with COVID-19.
  • To compare fever defervescence rates in pediatric patients treated with and without remdesivir.

Main Methods:

  • A retrospective cohort study design was employed.
  • Propensity-score matching was utilized to control for confounding variables between treatment groups.
  • Data were collected on pediatric patients diagnosed with COVID-19.

Main Results:

  • The rate of defervescence (fever reduction) by Day 4 was higher in the remdesivir group (86.7%) compared to the non-remdesivir group (73.3%).
  • This observed difference in defervescence rates did not reach statistical significance (P = 0.333).

Conclusions:

  • Remdesivir treatment in children with COVID-19 did not demonstrate a statistically significant improvement in fever reduction by Day 4.
  • The findings suggest that while remdesivir may be associated with faster fever resolution, further investigation is warranted to confirm its clinical utility in pediatric populations.

Keywords:
ChildrenCoronavirus disease 2019DefervescenceRemdesivirSevere acute respiratory syndrome coronavirus 2

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