Peripheral Blood Allogeneic Stem Cell Mobilization: Can We Predict a Suboptimal Mobilization?

Area of Science:

• Hematology
• Transplant Immunology
• Clinical Research

Background:

• Allogeneic peripheral blood stem cell (PBSC) mobilization is fundamental for transplants, but suboptimal mobilization can lead to complications.
• Current methods lack reliable criteria for early prediction of poor mobilization in healthy donors.

Approach:

• Analyzed PBSC donations (2013-2021) to identify factors predicting mobilization success.
• Collected data included donor age, gender, weight, baseline blood counts, G-CSF dose, and CD34+ cell counts.
• Developed a predictive score based on age and baseline white blood cell (WBC) count.

Key Points:

• Donor age (≤43 years) and lower baseline WBC count (<5.5×10^9/L) were associated with suboptimal mobilization.
• A predictive score incorporating these factors estimates the probability of poor mobilization (4-46%).
• The model explains 26% of mobilization variability, highlighting the role of genetic factors.

Conclusions:

• The suboptimal mobilization score offers a simple, early assessment tool for clinicians.
• This score aids in selecting donors and optimizing stem cell collection strategies.
• Findings are supported by a systematic review, suggesting clinical applicability for risk assessment and intervention.