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Updated: Jul 26, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
ST-elevation myocardial infarction after thrombolytic therapy with Tenecteplase for acute ischaemic stroke
Jorge Enrique Sinclair1, Marie Plante2, Michael F Harrison3
1Department of Critical Care Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA.
Abstract:
Myocardial infarction (MI) secondary to thrombolytic therapy in the setting of acute ischaemic stroke (AIS) is a rare but severe complication. This phenomenon has been well documented in the past with recombinant tissue-type plasminogen activator, also known as Alteplase. However, there are no documented reports of MI secondary to Tenecteplase (TNKase), an alternative thrombolytic agent rapidly gaining favour in managing AIS. We report a male patient in his 50s who received TNKase for an AIS and subsequently developed an inferolateral ST elevation MI.
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