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Published on: June 15, 2019
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Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression.
Alexis Garduno1, Rachael Cusack2, Marc Leone3
1Department of Clinical Medicine, Trinity College, University of Dublin, D02 PN40 Dublin, Ireland.
Microorganisms
|June 15, 2023
Summary
Late sepsis diagnosis leads to poor outcomes. Multi-omics and single-cell immunology can define sepsis endotypes for personalized therapy, improving patient survival.
Area of Science:
- Immunology
- Genomics
- Critical Care Medicine
Background:
- Sepsis and septic shock patients are often diagnosed late, leading to increased mortality.
- Current diagnostic methods are inaccurate and delayed, hindering timely treatment.
- Sepsis involves immune system paralysis after a "cytokine storm" and altered immune cell populations.
Purpose of the Study:
- To review the application of multi-omics data integration and single-cell immunological profiling for defining sepsis endotypes.
- To explore parallels between cancer immunosuppression and sepsis.
- To assess transcriptomic-driven endotypes for guiding immunomodulating therapies.
Main Methods:
- Narrative review of existing literature.
- Analysis of multi-omics data integration strategies.
- Examination of single-cell immunological profiling techniques.
- Review of transcriptomic data from clinical trials and studies.
Main Results:
- Delayed sepsis diagnosis contributes to poor patient outcomes and high mortality.
- Sepsis triggers significant changes in immune cell proportions and function.
- Multi-omics and single-cell analysis offer potential for precise endotyping.
- Transcriptomic data can inform continuous clinical response metrics.
Conclusions:
- Personalized endotyping through multi-omics and single-cell immunology is crucial for effective sepsis treatment.
- Understanding sepsis immunopathology, including parallels with cancer, can guide therapeutic strategies.
- Transcriptomic insights can support the use of immunomodulating agents in intensive care settings.
