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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

11
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
13

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Updated: Jul 26, 2025

Iris Fixation via External Pentagram Suturing
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Peripheral Ulcerative Keratitis Associated With Lichen Planus.

Yan Ning Neo1, Reem Farwana, Sarah Ahmoye

  • 1Corneal and External Disease Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Cornea
|June 15, 2023
PubMed
Summary
This summary is machine-generated.

Peripheral ulcerative keratitis (PUK) in a patient with lichen planus resolved with oral steroids and topical ciclosporin. Long-term topical ciclosporin maintained ocular surface stability, preventing relapse of this rare eye condition.

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Immunology

Background:

  • Lichen planus is a T-cell mediated autoimmune condition.
  • Ocular manifestations of lichen planus are uncommon, typically affecting the conjunctiva.
  • Peripheral ulcerative keratitis (PUK) is a severe inflammatory eye condition.

Observation:

  • A 42-year-old woman with confirmed lichen planus presented with bilateral PUK.
  • Standard PUK etiological screenings were negative.
  • The patient exhibited bilateral peripheral stromal thinning and epithelial defects.

Findings:

  • Treatment involved oral prednisolone, topical steroids, and topical ciclosporin.
  • PUK resolved within 3 months with systemic immunosuppression.
  • A maintenance regimen of topical ciclosporin prevented ocular surface inflammation relapse for over a year.

Implications:

  • Lichen planus can cause PUK, likely via shared T-cell autoimmune mechanisms.
  • Systemic immunosuppression is crucial for initial PUK management in this context.
  • Topical ciclosporin offers a viable long-term strategy for maintaining ocular surface health.