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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 18, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Recurrent DMEK Failures Related to Intraocular Tutoplast.

Soyang Ella Kim1, Reem Farwana, Alfonso Vasquez-Perez

  • 1Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.

Cornea
|September 10, 2025
PubMed
Summary
This summary is machine-generated.

Recurrent Descemet membrane endothelial keratoplasty (DMEK) failure occurred due to corneal contact with protruding Tutoplast after glaucoma surgery. Removing the implant resolved the issue, leading to a successful fourth DMEK procedure.

Keywords:
DMEKTutoplastrecurrent DMEK failure

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Glaucoma Management

Background:

  • Pseudophakic bullous keratopathy (PBK) can necessitate corneal transplantation.
  • Glaucoma surgeries may lead to complications like PBK.
  • Descemet membrane endothelial keratoplasty (DMEK) is a common endothelial keratoplasty technique.

Purpose of the Study:

  • To report a unique case of recurrent DMEK failure.
  • To identify the cause of DMEK failure in a patient with a history of PBK.
  • To highlight the role of intraocular implants and graft materials in DMEK outcomes.

Main Methods:

  • Retrospective case report.
  • Review of patient history and surgical procedures.
  • Clinical examination and assessment of corneal health.

Main Results:

  • A patient with PBK underwent three failed DMEK procedures.
  • Tutoplast material used to plug a sclerostomy was found to protrude into the anterior chamber.
  • Corneal contact with Tutoplast caused endothelial dysfunction and DMEK failure.

Conclusions:

  • This is the first reported case of DMEK failure linked to Tutoplast contact.
  • Thorough preoperative assessment is crucial to identify potential causes of graft failure.
  • Management of glaucoma implants and graft materials requires careful consideration in DMEK patients.