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Updated: Jul 20, 2026
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
Donor-implanted Guttata in Transplanted Corneal Tissue: Clinical Signs and Impact on Graft Survival
Arthur Hammer1, Ammatul Takaza2, Mark Lane1
1Moorfields Eye Hospital, NHS Foundation Trust, London, UK.
Purpose:
To present our experience with patients who developed donor-implanted guttata (DIG) following uncomplicated corneal endothelial transplantation.
Case Report:
Three patients who underwent Descemet membrane endothelial keratoplasty were diagnosed with DIG, which was confirmed by confocal microscopy. Two of the cases received corneas from the same donor and experienced delayed recovery of corneal transparency despite fully attached grafts.
Conclusion:
Fuchs endothelial dystrophy is a common condition within the general population and is likely to be present in donor corneas. We assessed three cases of DIG, and the results highlight the need for improved screening of this condition prior to transplantation and its consideration in the early postoperative period if corneal edema is present despite graft attachment.
