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Bifunctional Hydrogel-Integrated 3D Printed Scaffold for Repairing Infected Bone Defects
Qianqian Zhang1, Xiaojun Zhou1, Haibo Du1
1Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine; College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, P. R. China.
ACS Biomaterials Science & Engineering
|June 15, 2023
Summary
This study presents a novel dual-drug scaffold for treating infected bone defects, combining a 3D-printed structure with drug-eluting hydrogel. The innovative system effectively controls infection and promotes bone regeneration, offering a promising therapeutic approach.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Treating bone defects with coexisting infection is clinically challenging.
- Simultaneous infection control and bone defect repair is a key therapeutic goal.
Purpose of the Study:
- To develop a dual-drug delivery scaffold system for infected bone defect repair.
- To evaluate the efficacy of a composite scaffold integrating fingolimod and vancomycin.
Main Methods:
- Fabrication of a 3D printed polycaprolactone scaffold with fingolimod-loaded mesoporous silica nanoparticles.
- Preparation of a vancomycin-loaded hydrogel from aldehyde hyaluronic acid and carboxymethyl chitosan.
- Assessment of the composite scaffold's antimicrobial, biocompatibility, vascularization, and osteogenic properties in vitro and in vivo.
Main Results:
- The composite scaffold exhibited vancomycin concentration-dependent antimicrobial activity.
- FTY720-loaded scaffolds demonstrated good biocompatibility, vascularization, and osteogenic potential in vitro.
- The dual-drug scaffold significantly improved infection control and bone regeneration in a rat femoral defect model.
Conclusions:
- The developed bifunctional composite scaffold shows potential for treating infected bone defects.
- This system offers a promising strategy for simultaneous infection management and bone repair.
