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Updated: Jul 26, 2025

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Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
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A TCF-based fluorescent probe to determine nitroreductase (NTR) activity for a broad-spectrum of bacterial species
Kai-Cheng Yan1,2, Jordan E Gardiner1, Adam C Sedgwick3
1Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk.
Abstract:
A nitroreductase (NTR) responsive fluorescent probe with long wavelength fluorescence emission was used to determine the NTR activity of a selection of bacterial species under a range of different bacterial growth conditions ensuring applicability under multiple complex clinical environments, where sensitivity, reaction time, and the detection accuracy were suitable for planktonic cultures and biofilms.

