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Updated: Jun 23, 2026

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An Aptamer-based Sensor for Unchelated GadoliniumIII
Published on: January 9, 2017
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An activity-based fluorescent sensor with a penta-coordinate N-donor binding site detects Cu ions in living systems
1Department of Chemical Sciences, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Colaba, Mumbai-400005, India. ankona@tifr.res.in.
Abstract:
An activity-based sensor afforded a 63 times fluorescence-enhancement with Cu2+/Cu+ ions and could image Cu2+/Cu+ in living cells and in a multicellular organism. The sensor functioned only in the presence of ambient dioxygen and glutathione, and the characterization of intermediates and products hinted toward a sensing mechanism involving a CuII hydroperoxo species.

