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Updated: Jul 26, 2025

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Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems
Karolina Wojtczak1, Eva Zahorska2,3,4, Ian J Murphy1
1School of Biological and Chemical Sciences, University of Galway, University Road, Galway, Ireland. Joseph.byrne@ucd.ie.
Abstract:
Interactions of lectins with glycoconjugate-terbium(III) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.

