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Auxeticity as a Mechanobiological Tool to Create Meta-Biomaterials
Ebrahim Yarali1,2, Amir A Zadpoor1, Urs Staufer2
1Department of Biomechanical Engineering, Faculty of Mechanical Maritime and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628 CD Delft, The Netherlands.
ACS Applied Bio Materials
|June 15, 2023
Summary
Meta-biomaterials with unique properties like negative Poisson's ratios show promise for bone tissue engineering. Understanding their mechanobiology is key to developing advanced orthopedic implants and bone substitutes.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Cellular Mechanobiology
Background:
- Orthopedic implant design relies on mechanical properties like stiffness and porosity.
- The microarchitecture of porous scaffolds significantly impacts bone regeneration.
- Meta-biomaterials offer precise control over scaffold geometry and mechanical properties, including unusual Poisson's ratios.
Purpose of the Study:
- To review the effects of Poisson's ratio on meta-biomaterial performance in bone tissue engineering.
- To explore the mechanobiological interactions between meta-biomaterials and cells.
- To highlight additive manufacturing techniques for micro-scale meta-biomaterials.
Main Methods:
- Literature review focusing on meta-biomaterials and Poisson's ratio effects.
- Analysis of studies on cell interactions with meta-biomaterials.
- Examination of additive manufacturing techniques for scaffold fabrication.
Main Results:
- Meta-biomaterials enable independent tuning of mechanical properties like stiffness and Poisson's ratio.
- Unusual properties, such as negative Poisson's ratios (auxeticity), are explored for their biological impact.
- The review emphasizes the mechanobiological aspects of meta-biomaterial-cell interactions.
Conclusions:
- Further research is needed to clarify how unusual Poisson's ratios influence cell behavior and bone regeneration.
- Advanced additive manufacturing is crucial for creating micro-architected meta-biomaterials.
- Future meta-biomaterials may incorporate dynamic properties, such as those from 4D printing, for enhanced tissue engineering applications.
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