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Updated: Jul 26, 2025
09:56
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
673
Cellular Membrane Components-Mediated Cancer Immunotherapeutic Platforms.
Seojeong Yun1, Sungjun Kim1, Kyobum Kim1
1Department of Chemical & Biochemical Engineering, Dongguk University, Seoul, 04620, Republic of Korea.
Macromolecular Bioscience
|June 15, 2023
Summary
Cell membrane coating and nanovesicles offer biocompatible nanoscale biomedicine alternatives. These biomimetic approaches enhance nanoparticle circulation and function, paving the way for clinical applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Immunology
Background:
- Nanoparticles (NPs) face limitations in biomedical applications.
- Cell membrane coating and artificial nanovesicles offer biomimetic solutions.
- These methods leverage natural cell membrane characteristics for improved biocompatibility.
Purpose of the Study:
- To provide a comprehensive overview of cell membrane coating techniques and artificial nanovesicles.
- To summarize the function and application of various immune cell membrane types.
- To highlight the potential of these technologies in nanoscale biomedicine.
Main Methods:
- Review of existing literature on cell membrane coating techniques.
- Analysis of artificial nanovesicle technology.
- Summarization of immune cell membrane applications in biomimetic approaches.
Main Results:
- Cell membrane coating and artificial nanovesicles demonstrate good biocompatibility.
- These biomimetic strategies enable effective and extended in vivo circulation of NPs.
- They facilitate the execution of targeted functions through membrane-associated signaling.
Conclusions:
- Cell membrane-mediated biomimetic techniques are promising for overcoming NP limitations.
- Further research is needed for the clinical translation of coated NPs and artificial nanovesicles.
- Understanding immune cell membrane properties is crucial for optimizing these nanomedicine platforms.
Keywords:
artificial nanovesiclescancer immunotherapycell membranecell membrane-coated nanoparticlesimmune cellsreceptor/ligand interactionsMore Related Videos
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