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Updated: Jul 26, 2025
05:31
Purification and Visualization of Lipopolysaccharide from Gram-negative Bacteria by Hot Aqueous-phenol Extraction
Published on: May 28, 2012
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Lactic acid bacteria-derived exopolysaccharide: Formation, immunomodulatory ability, health effects, and
Jie Zhang1, Yue Xiao1, Hongchao Wang1
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Microbiological Research
|June 15, 2023
Summary
Lactic acid bacteria-derived exopolysaccharides (LAB-EPS) exhibit diverse health benefits and food functionalities. Their bioactivities and applications are closely linked to structural variations, offering significant commercial potential.
Area of Science:
- Microbiology
- Biochemistry
- Food Science
Background:
- Lactic acid bacteria (LAB) synthesize exopolysaccharides (EPSs) with significant implications for host health and food applications.
- The structural diversity of LAB-EPS, influenced by gene clusters and glycosyltransferases, leads to varied monosaccharide compositions.
- LAB-EPS are synthesized via extracellular or Wzx/Wzy-dependent pathways.
Purpose of the Study:
- To systematically summarize the synthesis, structure, bioactivities, and applications of LAB-EPS.
- To emphasize the physiological mechanisms and structure-function relationships of LAB-EPS.
- To provide theoretical support for the commercial value of LAB-EPS in various industries.
Main Methods:
- Review of scientific literature on LAB-EPS synthesis pathways.
- Analysis of structure-activity relationships, including monosaccharide composition, glycosidic bonds, and molecular weight.
- Examination of LAB-EPS physicochemical properties and their role in food applications.
Main Results:
- LAB-EPS possess strong immunomodulatory, antitumor, antioxidant, intestinal barrier repair, antimicrobial, antiviral, and cholesterol-lowering activities.
- Bioactivities are intrinsically linked to EPS structure, including monosaccharide composition, glycosidic bonds, and molecular weight.
- LAB-EPS enhance stability, emulsification, thickening, and gelling in dairy, bakery, and meat products.
Conclusions:
- LAB-EPS exhibit a wide range of health benefits and functional properties driven by their complex structures.
- The specific structure-function relationship of LAB-EPS is crucial for their bioactivities and applications.
- LAB-EPS hold substantial commercial potential in the pharmaceutical, chemical, food, and cosmetic industries.
Keywords:
Biosynthesis pathwayExopolysaccharideHealth effectsImmunomodulatory abilityLactic acid bacteriaStructure-function relationshipMore Related Videos
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