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Updated: Jul 26, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Applications of deep eutectic solvents in microextraction and chromatographic separation techniques: Latest
Asmaa Kamal El-Deen1, Nora Abdallah1, Heba Elmansi1
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Deep eutectic solvents (DESs) offer a green alternative in analytical chemistry, enhancing microextraction and chromatographic separation. This review explores their applications, performance improvements, and future potential in the field.
Area of Science:
- Analytical Chemistry
- Green Chemistry
Background:
- Deep eutectic solvents (DESs) are gaining attention as environmentally friendly alternatives to hazardous solvents.
- Their unique properties include biodegradability, low cost, ease of preparation, and tuneability.
Purpose of the Study:
- To review the applications of DESs in microextraction and chromatographic separation.
- To discuss the enhancements in chromatographic performance achieved using DESs.
- To outline current challenges and future trends in DESs research for analytical applications.
Main Methods:
- Literature review of DESs applications in analytical chemistry.
- Analysis of DESs utilization in sample preparation and chromatographic techniques.
- Discussion of DESs preparation, characterization, and properties.
Main Results:
- DESs have demonstrated significant potential in microextraction techniques.
- Their use as mobile phase additives and in chromatographic material preparation improves separation efficiency.
- Experimental findings suggest specific mechanisms for enhanced chromatographic performance.
Conclusions:
- DESs represent a promising class of solvents for advancing analytical chemistry, particularly in separation science.
- Further research into DESs offers distinct possibilities for developing novel analytical methodologies.
- This review serves as a guide for future research and development in DESs applications.
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