Correcting dysbiosis in the lungs of COPD, one pathogen at a time
Kendrew K Wong1, Leopoldo N Segal1
1Division of Pulmonary, Critical Care and Sleep Medicine, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
Abstract:
In this issue of Cell Host & Microbe, Liang et al. demonstrate through genomic analysis of the sputum microbiome from COPD patients and preclinical models that Staphylococcus aureus promotes lung function decline via regulation of homocysteine levels. Homocysteine can promote lung injury by promoting neutrophil apoptosis-to-NETosis shift via AKT1-S100A8/A9 axis.
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