Related Experiment Video
Updated: Jul 26, 2025
06:30
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
Published on: May 23, 2025
237
Comparison between hydroxychloroquine and systemic corticosteroids in IgA nephropathy: a two-year follow-up study
Feng-Lei Si1,2,3, Chen Tang1,2,3, Ji-Cheng Lv1,2,3
1Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
BMC Nephrology
|June 15, 2023
Summary
Hydroxychloroquine (HCQ) effectively controls proteinuria in IgA nephropathy (IgAN) over 24 months, comparable to corticosteroids (CSs). HCQ offers a safe alternative with fewer adverse events, maintaining stable renal function.
Area of Science:
- Nephrology
- Immunology
- Pharmacology
Background:
- IgA nephropathy (IgAN) is often treated with hydroxychloroquine (HCQ) to reduce proteinuria.
- Long-term efficacy and safety of HCQ versus systemic corticosteroids (CSs) in IgAN are not well-established.
Purpose of the Study:
- To compare the long-term effects of HCQ versus CS therapy on proteinuria and renal function in IgAN patients.
- To evaluate the safety profile of HCQ compared to CSs in IgAN management.
Main Methods:
- Retrospective case-control study at Peking University First Hospital.
- 39 IgAN patients receiving HCQ for ≥24 months (no other immunosuppressants) were matched with 39 IgAN patients receiving CS therapy.
- Clinical data, including proteinuria and estimated glomerular filtration rate (eGFR), were compared over 24 months.
Main Results:
- Both HCQ and CS groups showed significant proteinuria reduction at 24 months (HCQ: -50.5%; CS: -63.7%), with no significant difference between groups (P=0.707).
- Comparable decline rates in eGFR were observed between HCQ and CS groups (-7.9% vs. -6.6%, P=0.758).
- The CS group experienced more adverse events than the HCQ group.
Conclusions:
- Long-term hydroxychloroquine (HCQ) therapy for IgA nephropathy (IgAN) maintains stable renal function with minimal side effects.
- HCQ presents a safe and effective supportive treatment option for IgAN patients, particularly those intolerant to corticosteroids.
More Related Videos
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
10
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
10
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
161
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
161
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
315
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
315
01:24Nephrotic Syndrome I : Introduction
10
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
10
01:24Chronic Kidney Disease II: Clinical Manifestations
42
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
42
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
202
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
202