Theoretical analysis of the flux control properties of a substrate cycle

Substrate cycles are able to increase the flux control of a non-equilibrium reaction in a wide range of situations related to the effects of the metabolites involved in the cycle on the reaction producing them. No limit exists for that amplification if appropriate conditions are attained if those effects are positive. In all cases, the ratio between the rate of the reverse reaction and the net flux through the pathway plays an important role in defining the final amplification.