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Histidine-DNA nanoarchitecture as laccase mimetic DNAzymes
Ji Hye Yum1, Tomotaka Kumagai1, Daisuke Hori1
1Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
Nanoscale
|June 16, 2023
Abstract:
Herein, we report on the construction of Cu-histidine (His)-DNA hybrids as laccase-mimetic DNAzymes. Cu-His-DNAzymes showed remarkable activity in a colorimetric oxidation reaction between 2,4-dichlorophenol and 4-aminoantipyrine. Our results provide new insights for the systematic construction of tailor-made active sites for biomimetics.

