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Updated: Jul 26, 2025
Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
Published on: June 9, 2023
Recent advances of Au@Ag core-shell SERS-based biosensors
Gul Awiaz1,2, Jie Lin1,3, Aiguo Wu1,3
1Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering, CAS Ningbo China.
Surface-enhanced Raman scattering (SERS) biosensors using gold/silver nanomaterials offer highly sensitive detection of biological molecules. This review details advancements in Au/Ag bimetallic SERS biosensors and their applications, including COVID-19 protein detection.
Area of Science:
- Nanotechnology
- Spectroscopy
- Biochemistry
Background:
- Surface-enhanced Raman scattering (SERS) utilizes noble metal nanomaterials for ultrasensitive molecule detection.
- Gold (Au), silver (Ag), and their bimetallic alloys (Au-Ag) are key materials for SERS substrates.
- Advancements in nanoscale materials have significantly improved SERS sensitivity for chemical and biological sensing.
Purpose of the Study:
- To review recent developments in SERS-based biosensors utilizing Au/Ag bimetallic nanomaterials.
- To analyze the Raman enhanced activity influenced by material properties.
- To highlight the impact of structural variations on SERS performance.
Main Methods:
- Focus on Au/Ag bimetallic nanomaterials as substrates for SERS.
- Investigation of factors affecting Raman enhancement, including size, shape, and core-shell morphology.
- Review of recent biological applications and detection capabilities.
Main Results:
- Au/Ag bimetallic nanomaterials demonstrate high efficiency in SERS-based biosensing.
- Material properties like size, shape, and morphology significantly influence Raman enhancement.
- Successful application in detecting various biomolecules, including proteins, DNA, RNA, and the COVID-19 RBD protein.
Conclusions:
- SERS-based Au/Ag bimetallic biosensors represent a revolutionary advancement in molecular detection.
- Understanding the structure-property relationships is crucial for optimizing SERS performance.
- These biosensors show significant potential for diverse biological and medical applications, including disease diagnostics.
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