Related Experiment Videos
Effect of food on cibenzoline bioavailability
European Journal of Clinical Pharmacology
|January 1, 1986
Summary
Food intake does not significantly alter cibenzoline bioavailability. Taking cibenzoline with or after a meal slightly reduces absorption rate but does not impact overall drug extent of absorption.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Metabolism
Background:
- Cibenzoline is an antiarrhythmic drug.
- Understanding food effects on drug pharmacokinetics is crucial for optimal dosing.
- Previous studies on cibenzoline's food effect are limited.
Purpose of the Study:
- To investigate the impact of food on the pharmacokinetic profile of orally administered cibenzoline.
- To determine if food influences the rate and extent of cibenzoline absorption.
Main Methods:
- An open-label, four-way randomized crossover study was conducted.
- Eighteen healthy adult volunteers received 160 mg oral cibenzoline doses.
- Drug administration occurred under fasting conditions, 1 hour before, with, and 1 hour after a standard breakfast.
Main Results:
- No significant changes in bioavailability parameters were observed when cibenzoline was taken 1 hour before food compared to fasting.
- Administration with or 1 hour after food resulted in a slight decrease in the rate of absorption.
- The extent of cibenzoline absorption remained unaltered regardless of food intake.
Conclusions:
- Food does not significantly affect the overall bioavailability of cibenzoline.
- The observed slight decrease in absorption rate with food is not considered clinically significant.
- Cibenzoline can be administered without strict regard to meal timing.