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Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
Published on: September 10, 2021
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SARS-CoV-2 and gastrointestinal diseases
Ailong Sha1,2, Yi Liu2, Xuewen Zhao2
1School of Teacher Education, Chongqing Three Gorges University, Chongqing, China.
Frontiers in Microbiology
|June 16, 2023
Summary
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) impacts the digestive system, causing various gastrointestinal diseases. Understanding these SARS-CoV-2 gastrointestinal issues and damage mechanisms is vital for effective treatment.
Area of Science:
- Gastroenterology
- Virology
- Infectious Diseases
Background:
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary cause of the COVID-19 pandemic.
- The virus affects not only the respiratory system but also the digestive tract, leading to diverse gastrointestinal manifestations.
Purpose of the Study:
- To review gastrointestinal diseases associated with SARS-CoV-2.
- To analyze the mechanisms of SARS-CoV-2-induced gastrointestinal injury.
- To provide drug prevention and treatment recommendations for clinicians.
Main Methods:
- Literature review of studies on SARS-CoV-2 and gastrointestinal diseases.
- Analysis of pathogenic mechanisms of SARS-CoV-2 in the gastrointestinal tract.
- Synthesis of current knowledge on clinical manifestations and therapeutic strategies.
Main Results:
- SARS-CoV-2 causes gastrointestinal inflammatory disorders, ulcer diseases, bleeding, and thrombotic diseases.
- Mechanisms of injury involve direct viral invasion and host immune responses.
- Specific therapeutic targets and drug strategies are identified.
Conclusions:
- Gastrointestinal symptoms are a significant feature of COVID-19.
- Understanding viral pathogenesis is key to managing GI complications.
- Evidence-based treatment recommendations are crucial for patient care.
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