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Complete Blood Count Parameters as Prognostic Factor of Stroke: A Systematic Review

Samad Shams Vahdati1, Alireza Ala1, Nafiseh Vahed2

  • 1Emergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.

Basic and Clinical Neuroscience
|June 16, 2023
PubMed

Insights

Complete blood count (CBC) tests can help predict stroke outcomes. Elevated red blood cell distribution width and hemoglobin levels are linked to poorer stroke prognosis and mortality.

Area of Science:

  • Neurology
  • Hematology
  • Public Health

Background:

  • Stroke is a leading cause of long-term disability globally.
  • Accurate prognosis estimation is crucial for patient management and resource allocation.

Purpose of the Study:

  • To systematically review the prognostic value of complete blood count (CBC) laboratory findings in stroke patients.
  • To identify specific CBC parameters that can predict stroke outcomes.

Main Methods:

  • A systematic literature search was conducted across major databases (Medline, Embase, Scopus, Cochrane, ProQuest) from 1988 to 2020.
  • Keywords included "Stroke", "Red Cell Distribution Width", "Blood Cell Count", "Mean corpuscular hemoglobin", and "Mean Corpuscular Volume".
  • Data synthesis was performed using content analysis.

Main Results:

  • Elevated red blood cell distribution width (RDW) is associated with increased risk of stroke, cardiovascular events, and all-cause mortality in stroke survivors.
  • Hemoglobin and globulin levels can predict short-term mortality after acute ischemic stroke.
  • Mean platelet volume and mean corpuscular volume (MCV) showed limited prognostic significance in ischemic stroke.

Conclusions:

  • Complete blood count (CBC) parameters offer valuable prognostic information for stroke.
  • CBC is a readily available and cost-effective tool for assessing stroke prognosis in clinical settings.
Abstract

Keywords:
Blood cell countErythrocyte indicesPrognosisStroke

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