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Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by

Haibao Peng1, Feibai Yao1, Jiaxu Zhao1

  • 1Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science Fudan University Shanghai China.

Exploration (Beijing, China)
|June 16, 2023
PubMed

Insights

Mitochondria play a key role in cancer. Targeting mitochondria with nanomaterials to control reactive oxygen species (ROS) offers a promising precision medicine strategy for cancer therapy.

Area of Science:

  • Mitochondrial biology
  • Cancer research
  • Nanomedicine

Background:

  • Mitochondria are vital for cellular respiration and are implicated in cancer progression.
  • Mitochondria produce and accumulate reactive oxygen species (ROS), leading to oxidative damage.
  • Mitochondrial dysfunction is a hallmark of cancer, influencing tumor growth and development.

Purpose of the Study:

  • To review the role of mitochondria in cancer.
  • To explore the potential of targeting mitochondria with nanomaterials for cancer therapy.
  • To discuss strategies for manipulating mitochondrial redox homeostasis using ROS-generating nanomaterials.

Main Methods:

  • Literature review of seminal work on mitochondria, cancer, and nanomaterials.
  • Analysis of how nanomaterial modifications can influence ROS generation.
  • Discussion of research challenges and commercialization perspectives for mitochondria-targeting agents.

Main Results:

  • Mitochondria are central to cancer cell metabolism and survival.
  • Reactive oxygen species (ROS) accumulation in mitochondria contributes to cancer development.
  • Nanomaterials can be engineered to modulate mitochondrial ROS levels, impacting cancer cells.

Conclusions:

  • Targeting mitochondrial redox homeostasis represents a viable precision medicine approach for cancer treatment.
  • Engineered nanomaterials offer a platform for developing novel mitochondria-targeting cancer therapeutics.
  • Further research and development are needed for the clinical translation of these agents.
Keywords:
cancer therapymitochondria‐targetingnanomaterialsreactive oxygen species

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