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Updated: Jul 26, 2025

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience

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Neoadjuvant Chemotherapy Followed by Cystectomy: a Single-Center Experience.

R B Nerli^1,2, Shridhar C Ghagane^1,2, Rangrez Shadab¹

¹Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-To-Be-University), JNMC Campus, Nehru Nagar, Belagavi, 590010 India.

Indian Journal of Surgical Oncology

|June 16, 2023

Summary

Neoadjuvant chemotherapy before radical cystectomy offers a safe and effective treatment for muscle-invasive bladder cancer. This approach shows promise in improving outcomes for patients with locally advanced disease.

Keywords:

Adverse drug reactions Bladder cancer Neoadjuvant chemotherapy Radical cystectomy

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Area of Science:

Urology
Oncology
Medical Oncology

Background:

Muscle-invasive bladder cancer (MIBC) frequently metastasizes after cystectomy alone.
Cisplatin-based chemotherapy demonstrates efficacy in bladder cancer treatment.
Neoadjuvant chemotherapy prior to cystectomy is being investigated for advanced bladder cancer.

Purpose of the Study:

To retrospectively evaluate the safety and effectiveness of neoadjuvant chemotherapy followed by radical cystectomy in patients with MIBC.

Main Methods:

Retrospective review of 72 patients with MIBC undergoing neoadjuvant chemotherapy and radical cystectomy between 2005 and 2019.
Analysis of patient demographics, chemotherapy completion rates, and survival outcomes.
Assessment of treatment safety and monitoring for chemotherapy-induced toxicities.

Main Results:

The median patient age was 59.8 years (male to female ratio 5:1).
50% of patients died during follow-up; mean survival was 84.85 months, median survival was 91.0 months.
Neoadjuvant MVAC chemotherapy was generally safe and effective in patients with adequate renal function.

Conclusions:

Neoadjuvant chemotherapy, specifically MVAC, is recommended for eligible MIBC patients undergoing radical cystectomy.
Careful monitoring for chemotherapy toxicity is crucial for patient safety.
This approach can be a valuable component of treatment for locally advanced bladder cancer.