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Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

1.0K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
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Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

12
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
12
Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Related Experiment Video

Updated: Jul 26, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Genome and atrial fibrillation.

Yukiko Nakano1

  • 1Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan.

Journal of Arrhythmia
|June 16, 2023
PubMed
Summary

Genetic predisposition plays a key role in atrial fibrillation (AF), the most common heart arrhythmia. Recent genetic analyses are advancing our understanding of AF

Area of Science:

  • Cardiology
  • Genetics
  • Medical Research

Background:

  • Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia.
  • AF leads to severe health issues including stroke, heart failure, cognitive decline, reduced quality of life, and increased mortality.
  • Both genetic factors and clinical predispositions contribute to AF development.

Purpose of the Study:

  • To review current trends in the genetic analysis of atrial fibrillation.
  • To elucidate the relationship between genes and the pathogenesis and prognosis of AF.

Main Methods:

  • Review of genetic studies on AF.
  • Analysis of linkage studies.
  • Examination of genome-wide association studies (GWAS).
  • Evaluation of polygenic risk scores.
Keywords:
GWASatrial fibrillationgenomepolygenic risk factor

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  • Studies on rare coding variations.

    • Main Results:

    • Genetic studies have significantly advanced the understanding of AF.
    • Various genetic approaches are progressively clarifying the genetic underpinnings of AF.
    • The interplay between genetic variations and AF development is becoming clearer.

    Conclusions:

    • Genetic analysis is crucial for understanding AF.
    • Continued research in AF genetics promises to improve diagnosis and treatment.
    • Genetic insights are vital for managing AF pathogenesis and prognosis.