Successful Defibrillation After Conversion From Fixed-Tilt to Tuned-Duration Waveform
Yousaku Okubo1, Hisayasu Matsuzaki2, Shogo Miyamoto1
1Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan.
Abstract:
Fixed-tilt biphasic shocks may become ineffective in high-impedance states because phase-2 over-prolongation disrupts optimal charge neutralization. Waveform tuning based on membrane time constants, as implemented by DeFT Response, shortens phase durations to physiologic ranges and lowers the defibrillation threshold. This mechanism-based strategy may enhance the reliability of ICD therapy in patients with rising impedance or high DFTs.
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