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Updated: Jul 26, 2025

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
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Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin

Waly Dioh1, Vihang Narkar2, Anurag Singh3

  • 1Biophytis, UMPC-BC9, Paris, France.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|June 16, 2023
PubMed

Insights

New therapies like Mas receptor agonists and mitophagy regulators show promise for improving physical function in older adults. Research is advancing novel treatments for age-associated mobility loss.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Pharmacology of Aging

Background:

  • Age-associated mobility loss and disability are significant concerns in older adults.
  • Current treatment paradigms are insufficient for addressing these challenges effectively.

Purpose of the Study:

  • To summarize recent advancements in novel therapeutic compounds targeting age-related functional decline.
  • To review preclinical and clinical data on the safety and efficacy of these emerging therapies.

Main Methods:

  • Review of recent scientific literature on novel therapeutic classes.
  • Analysis of preclinical and clinical data for function-promoting compounds.
  • Focus on Mas receptor agonists, mitophagy regulators, skeletal muscle troponin activators, anti-inflammatory compounds, and orphan nuclear receptor targets.

Main Results:

  • Several novel therapeutic classes demonstrate potential for restoring physical functioning in older adults.
  • Preclinical and clinical data indicate varying degrees of safety and efficacy for these compounds.
  • Emerging treatments include Mas receptor agonists and regulators of mitophagy.

Conclusions:

  • Novel compounds are expanding the therapeutic landscape for age-associated mobility loss.
  • A new treatment paradigm is likely necessary to combat age-related disability.
  • Continued research into these therapies holds significant promise for improving geriatric health.
Keywords:
Mas receptorMitophagy regulatorsOrphan nuclear receptorsPhysical functionSkeletal muscle dysfunctionTroponin activators

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