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Related Experiment Videos

Development of the surgically produced singleton mouse fetus.

R Gandelman, S Graham

    Developmental Psychobiology
    |July 1, 1986
    PubMed
    Summary

    Mouse pups born as singletons, with fewer siblings in utero, showed accelerated development. These singleton mice were heavier and reached developmental milestones earlier than their littermate controls.

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    Area of Science:

    • Developmental biology
    • Reproductive science
    • Animal models

    Background:

    • Maternal uterine crowding can impact fetal development.
    • Understanding singleton development is crucial for reproductive health research.

    Purpose of the Study:

    • To investigate the developmental impact of singleton gestation in a mouse model.
    • To compare developmental trajectories of singleton mice versus controls with normal litter sizes.

    Main Methods:

    • Surgical removal of mouse embryos on Day 8 of gestation, with subsequent cesarean delivery on Day 18.
    • Comparison of developmental indices between singleton and control groups.
    • Observation of prenatal activity and physical developmental milestones.

    Main Results:

    • Singleton mice were heavier at birth and weaning compared to controls.
    • Singletons exhibited smaller ano-genital distance ratios.
    • Accelerated onset of walking, gripping, eye-opening, and vaginal-opening in singletons.
    • Increased duration and frequency of prenatal activities observed in singletons.

    Conclusions:

    • Singleton gestation in mice leads to accelerated physical and behavioral development.
    • Reduced litter size influences key developmental milestones and growth parameters.
    • This model provides insights into the effects of developmental environment on offspring outcomes.

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