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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Jul 26, 2025

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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TFEB: a double-edged sword for tumor metastasis.

Jun-Hu Hu1,2, Shou-Ye Li3,4, Li-Hua Yu1,2

  • 1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.

Journal of Molecular Medicine (Berlin, Germany)
|June 16, 2023
PubMed
Summary

Transcription factor EB (TFEB) plays a dual role in tumor metastasis, influencing processes like autophagy and EMT. Further research is needed to clarify TFEB

Keywords:
ActivationMetastasisPhosphorylationTFEBTumor

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Background:

  • Transcription factor EB (TFEB) is a key regulator of cellular processes including autophagy and lysosome biogenesis.
  • Tumor metastasis is a major challenge in cancer therapy, and the role of TFEB in this process is complex and debated.
  • TFEB belongs to the microphthalmia-associated transcription factor (MiTF/TFE) family.

Purpose of the Study:

  • To review and elucidate the multifaceted mechanisms by which TFEB regulates tumor metastasis.
  • To discuss the contradictory roles of TFEB in promoting or inhibiting cancer cell metastasis.
  • To explore the signaling pathways involved in TFEB activation and inactivation relevant to metastasis.

Main Methods:

  • Literature review of studies investigating the role of TFEB in tumor metastasis.
  • Analysis of TFEB's impact on autophagy, epithelial-mesenchymal transition (EMT), lysosomal biogenesis, lipid metabolism, and oncogenic signaling.
  • Examination of TFEB regulation by pathways such as mTORC1, Rag GTPase, ERK2, and AKT.

Main Results:

  • TFEB positively influences metastasis through autophagy, EMT, lysosomal biogenesis, lipid metabolism, and oncogenic signaling.
  • Conversely, TFEB negatively impacts metastasis by affecting tumor-associated macrophages (TAMs) and EMT.
  • Specific pathways regulating TFEB activation and inactivation (mTORC1, Rag GTPase, ERK2, AKT) are identified.

Conclusions:

  • TFEB exhibits a dual role in tumor metastasis, with significant implications for therapeutic strategies.
  • The precise mechanisms of TFEB-mediated metastasis regulation require further in-depth investigation.
  • Understanding TFEB's complex functions is crucial for developing novel anti-metastasis treatments.