Related Experiment Video

Updated: Jul 26, 2025

Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis

Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis

Published on: December 8, 2023

C₁₉-diterpenoid alkaloids from Aconitum refractum var. circinatum

Zhen-Ling Wan^1,2, Min Zhang^1,2, Yan Xiao¹

¹School of Life Science and Engineering Southwest, Jiaotong University, Chengdu, Sichuan, P. R. China.

Natural Product Research

|June 17, 2023

Abstract:

Two unprecedented aconitine-type C19-diterpenoid alkaloids, refractines A-B (1-2), along with 12 known compounds (3-14) were isolated from the roots of Aconitum refractum (Finet et Gagnep.) Hand. -Mazz. Their structures were elucidated based on extensive spectroscopic analyses, including 1D and 2D NMR, IR, and HR-ESI-MS data. All compounds were tested for inhibitory activities against NO production in LPS induced RAW 264.7 macrophages, compounds 10 and 14 had slight inhibited NO production with rate of 29.4% and 22.1% at the concentration of 30 μM, respectively.

Keywords:

Aconitum refractum anti-inflammatory activity diterpenoid alkaloids ranunculaceae

More Related Videos

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Published on: May 12, 2023

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Published on: March 8, 2024

Related Concept Videos

Physical Properties of Amines

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...

Articles linked to this work by shared authors, journal, and citation graph.

Machine learning-driven investigation of key flavor factors in pale lager beer fermentation samples and their evolution mechanisms during fermentation.

Food chemistry·2026

Comorbid Insomnia is Associated with Enhanced Blood Pressure Reduction with CPAP Therapy in Patients with Obstructive Sleep Apnea: A Prospective Cohort Study.

Chest·2026

Predicting range expansion of three tropical fruit flies and risks to pome and stone fruit production in temperate regions.

Journal of economic entomology·2026

The relationship between physical activity and quality of life among community-dwelling middle-aged and older adults with type 2 diabetes: a chain mediation model of psychological resilience and exercise self-efficacy.

Frontiers in endocrinology·2026

Mining and Validation of Novel Umami Peptides in Non-Alcoholic Beer by Integrating Machine Learning Prediction, Molecular Docking, and Sensory Validation, and Their Multidimensional Sensory Impacts on Beer Body.

Foods (Basel, Switzerland)·2026

Identification and Sensory Characterization of Umami Peptides During Lager Beer Fermentation.

Foods (Basel, Switzerland)·2026

See all related articles