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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
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Adipose Tissue Dysfunction in Polycystic Ovary Syndrome
Fernando Bril1, Uche Ezeh2,3, Mina Amiri4
1Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL 35233, USA.
The Journal of Clinical Endocrinology and Metabolism
|June 17, 2023
Summary
Adipose tissue dysfunction, not obesity, drives metabolic and inflammatory issues in Polycystic Ovary Syndrome (PCOS). Further research is needed to clarify mechanisms and treatments for this common endocrine disorder.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Reproductive Health
Background:
- Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting 5-15% of women globally.
- PCOS is characterized by complex genetic factors and associated cardiometabolic dysfunction.
- Adipose tissue (AT) dysfunction plays a key role in PCOS pathophysiology, even without excess adiposity.
Conclusions:
- Adipose tissue (AT) dysfunction is a more significant contributor to metabolic and inflammatory abnormalities in PCOS than AT distribution or excess adiposity.
- Existing data is often contradictory or limited, underscoring the need for further research.
- Targeting AT dysfunction holds potential for PCOS treatment strategies.
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