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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Related Experiment Video

Updated: Jul 26, 2025

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
13:57

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Published on: May 23, 2025

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Risk factors and outcomes for cholangitis after hepatic resection.

Christopher W Mangieri1, Matthew A Strode2, Omeed Moaven3

  • 1Department of Surgery, Division of Surgical Oncology, Wake Forest University Baptist Health Medical Center, Winston-Salem, USA. christopher.w.mangieri.mil@health.mil.

Langenbeck'S Archives of Surgery
|June 17, 2023
PubMed
Summary

Post-operative cholangitis after liver resection is rare but serious. Biliary anastomosis and pre-operative stenting significantly increase the risk of this complication, leading to severe outcomes.

Keywords:
CholangitisHepatic resectionSurgical Outcomes

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Area of Science:

  • Hepatobiliary surgery
  • Surgical oncology
  • Gastroenterology

Background:

  • Limited literature exists on the incidence, risk factors, and outcomes of post-operative cholangitis following hepatic resection.
  • Understanding these factors is crucial for improving patient safety and surgical outcomes.

Purpose of the Study:

  • To determine the incidence and identify risk factors for post-operative cholangitis after hepatic resection.
  • To analyze the outcomes associated with post-operative cholangitis in this patient population.

Main Methods:

  • Retrospective review of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) registries.
  • Analysis of data from 2012-2016, including main and targeted hepatectomy procedures.
  • Multivariate analysis to identify significant risk factors and outcomes.

Main Results:

  • The incidence of post-operative cholangitis was 0.64% (151 out of 11,243 cases).
  • Significant risk factors included biliary anastomosis (OR 32.39) and pre-operative biliary stenting (OR 18.32).
  • Cholangitis was associated with increased bile leaks, liver/renal failure, infections, sepsis, reoperation, longer hospital stay, readmissions, and mortality.

Conclusions:

  • This is the largest analysis to date of post-operative cholangitis following hepatic resection.
  • Although rare, cholangitis significantly increases the risk of severe morbidity and mortality.
  • Biliary anastomosis and stenting are the most critical risk factors identified.