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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Related Experiment Video

Updated: Jul 26, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

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Advances in Osteosarcoma.

Isidora Panez-Toro1,2, Javier Muñoz-García3,4, Jorge W Vargas-Franco5

  • 1Nantes Université, CNRS, UMR6286, US2B, Biological Sciences and Biotechnologies unit, 44322, Nantes, France.

Current Osteoporosis Reports
|June 17, 2023
PubMed
Summary
This summary is machine-generated.

New osteosarcoma treatments focus on signaling pathways and immunotherapy, but clinical trials show limited improvement over chemotherapy. Further research into the tumor microenvironment is crucial for developing effective therapies for this bone cancer.

Keywords:
Immune checkpoint inhibitorImmunotherapyOsteosarcomaPersonalized medicineTumor microenvironmentTumor targeted therapy

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Area of Science:

  • Oncology
  • Orthopedic Surgery
  • Cancer Research

Background:

  • Osteosarcoma is a primary malignant bone tumor common in young adults.
  • It has a high risk of metastasis and a 5-year survival rate of 30% with metastases.
  • Conventional chemotherapy has shown limited improvement over four decades.

Purpose of the Study:

  • To review recent advancements in osteosarcoma treatment.
  • To explore novel therapeutic targets and strategies.
  • To address the challenges posed by this heterogeneous disease.

Main Methods:

  • Review of recent developments in osteosarcoma treatment.
  • Analysis of targeted signaling pathways.
  • Evaluation of immune checkpoint inhibitors and drug delivery strategies.

Main Results:

  • Emerging immunotherapies, including immune checkpoint inhibitors, offer new treatment paradigms.
  • Recent clinical trials show only slight improvements over conventional polychemotherapy.
  • The tumor microenvironment significantly influences osteosarcoma progression and drug resistance.

Conclusions:

  • Despite advances, effective osteosarcoma treatment requires further innovation.
  • Targeting signaling pathways, immunotherapy, and novel drug delivery are promising avenues.
  • Understanding the tumor microenvironment is key to developing future therapeutic options.