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Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
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Trichodermatides A-D, four new polyketides from Trichoderma sp. XM-3.

Peng Zhou1, Jie Cao2, Hucheng Zhu3

  • 1Editoral Department of Journals, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

Fitoterapia
|June 17, 2023
PubMed
Summary
This summary is machine-generated.

Researchers isolated four new polyketides, trichodermatides A-D, from Trichoderma sp. XM-3 fungus. One compound, Trichodermaketone D, demonstrated mild antibacterial activity against Pseudomonas aeruginosa.

Keywords:
Antibacterial activityPolyketidesTrichoderma sp.X-ray diffraction analyses

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Area of Science:

  • Natural Products Chemistry
  • Mycology
  • Organic Chemistry

Background:

  • Fungal secondary metabolites, particularly polyketides, are a rich source of novel chemical structures.
  • The genus Trichoderma is known for producing a diverse array of bioactive compounds.

Purpose of the Study:

  • To isolate and characterize new polyketides from the fungus Trichoderma sp. XM-3.
  • To investigate the potential bioactivity of the isolated compounds.

Main Methods:

  • Structure elucidation using High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS) and Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Determination of absolute configurations via Electronic Circular Dichroism (ECD) comparison, NMR calculations, DP4+ analysis, modified Mosher's method, and X-ray crystallography.
  • Bioactivity screening, including antibacterial assays.

Main Results:

  • Four new polyketides, trichodermatides A-D (1-4), were isolated and structurally characterized.
  • Five known analogues (5-9) were also identified.
  • Trichodermaketone D (9) exhibited mild antibacterial activity against Pseudomonas aeruginosa.

Conclusions:

  • The study expands the chemical diversity of polyketides from Trichoderma species.
  • Trichodermaketone D represents a potential lead compound for further investigation of antibacterial agents.