Related Experiment Video

Updated: Jul 26, 2025

An Intact Pericardium Ischemic Rodent Model
07:15

An Intact Pericardium Ischemic Rodent Model

Published on: September 2, 2021

2.5K

Pericardial fat and cardiovascular diseases: A systematic review and meta-analysis

Hanna K Al-Makhamreh1, Ahmad A Toubasi2, Layla M Al-Harasis3

  • 1Cardiology Section, Faculty of Medicine, Department of Internal Medicine, University of Jordan, Amman, Jordan.

Journal of Evidence-Based Medicine
|June 19, 2023
PubMed

Insights

Pericardial fat is significantly linked to various cardiovascular diseases, including coronary artery disease and heart failure. Further research may incorporate pericardial fat into cardiovascular risk scores.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Obesity Research

Background:

  • Pericardial fat accumulation is increasingly recognized as a risk factor for cardiovascular diseases.
  • Previous studies have explored this association, but a comprehensive systematic review and meta-analysis was lacking.

Approach:

  • A systematic literature search was conducted across major databases (PubMed, Cochrane Library, Scopus, Google Scholar, Clinicaltrials.gov).
  • Observational studies investigating the relationship between pericardial fat and cardiovascular diseases were included.
  • Data analysis was performed using Meta XL 5.3.

Key Points:

  • The meta-analysis included 83 studies with 73,934 patients.
  • Significant associations were found between pericardial fat and coronary artery disease (CAD), ventricular dysfunction, heart failure (HF), atrial fibrillation (AF), major adverse cardiac events (MACE), and coronary artery calcifications (CAC).
  • Insufficient data precluded analysis of pericardial fat's relationship with other arrhythmias or cardiovascular risk scores.

Conclusions:

  • Pericardial fat volume is significantly associated with multiple cardiovascular diseases.
  • Given its link to obesity, pericardial fat warrants further investigation as a potential addition to existing cardiovascular risk assessment tools.
Abstract

Keywords:
atrial fibrillationcardiovascular diseasescoronary artery diseaseheart failurehumanpericardial fatventricular dysfunction

More Related Videos

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.9K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.0K

Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
16
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
13
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
12
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
33
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
3.2K
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
21