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Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review

Zihan Masood1, Joseph S Domino1, Antonia Gragg2

  • 1Department of Neurosurgery, University of Kansas Medical Center, US.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|June 19, 2023
PubMed

Insights

Unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi) shows promise for treating medically refractory hemichorea (HC) and hemiballismus (HB). This surgical intervention led to significant symptom improvement in reported cases.

Area of Science:

  • Neurology
  • Neurosurgery
  • Movement Disorders

Background:

  • Hemichorea (HC) and hemiballismus (HB) are rare movement disorders.
  • These conditions can be resistant to medical treatments, necessitating surgical options.

Approach:

  • This study reports on 3 patients with HC-HB who underwent unilateral deep brain stimulation (DBS) targeting the globus pallidus interna (GPi).
  • A review of 8 prior cases treated with GPi-DBS for HC-HB was also conducted.

Key Points:

  • All 3 reported patients experienced meaningful clinical improvement following unilateral GPi-DBS.
  • A majority of the 8 previously reported patients also showed significant symptom improvement.

Conclusions:

  • Unilateral GPi-DBS is a potential surgical consideration for carefully selected patients with medically refractory HC-HB.
  • Further research is required due to the limited data from small case series.
Abstract

Keywords:
Hemiballismusdeep brain stimulationhyperkinetic movement disorder

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