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Related Experiment Video

Updated: Jul 26, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
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A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening.

Shalaka Chitale, Wenxuan Wu, Avik Mukherjee

    Biorxiv : the Preprint Server for Biology
    |June 19, 2023
    PubMed
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    This summary is machine-generated.

    A new semiconductor microplate platform enables high-resolution, real-time impedance imaging of live cells at scale. This technology advances label-free, functional cell analysis for drug discovery and mechanism of action profiling.

    Area of Science:

    • Biotechnology
    • Cell Biology
    • Drug Discovery

    Background:

    • High-content imaging is popular for drug discovery but limited to fixed cells.
    • Existing label-free electronic devices lack high resolution or throughput.
    • There is a need for scalable, high-resolution live-cell analysis platforms.

    Conclusions:

    • The semiconductor platform offers scalable, high-resolution, real-time live-cell impedance imaging.
    • The platform enables functional parameter capture for phenotypic drug discovery.
    • This technology enhances high-throughput MOA profiling and drug discovery applications.

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