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Updated: Jul 26, 2025
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
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Heritable epigenetic changes are constrained by the dynamics of regulatory architectures
1University of Maryland, College Park, MD, USA.
Biorxiv : the Preprint Server for Biology
|June 19, 2023
Summary
Molecular architectures can transmit epigenetic changes across generations. Positive feedback loops are crucial for heritability, enabling stable alterations or architectural collapse, as seen in C. elegans RNA silencing.
Area of Science:
- Systems Biology
- Epigenetics
- Molecular Biology
Background:
- Molecular interactions form regulatory architectures that can persist despite molecular turnover.
- Epigenetic changes occur within these architectures, but their influence on heritability is poorly understood.
Conclusions:
- Differential inhibition of feedback loops explains C. elegans RNA silencing variations.
- Provides a framework for analyzing epigenetic inheritance within molecular regulatory architectures.
- Applicable to diverse living systems and molecular implementations.
Keywords:
RNA silencingheredityplasticitypositive feedbackrobustnesstransgenerational epigenetic inheritanceMore Related Videos
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