Related Experiment Video
Updated: Jul 26, 2025

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
Published on: June 2, 2023
Pyrrole alkaloids from the fruiting bodies of edible mushroom Lentinula edodes
Zhen-Zhu Zhao1, Fei Zhang1, Bao-Yu Ji1
1School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046 China fwsh@hactcm.edu.cn zhengxk.2006@163.com.
Abstract:
Nine pyrrole alkaloid derivatives, including four new ones (1-4), were isolated from the wild mushroom Lentinula edodes for the first time. Their chemical structures were determined using UV-Vis spectroscopy, IR spectroscopy, MS, NMR spectroscopy, and single-crystal X-ray diffraction techniques. Compound 1, a previously unreported bicylo-pyrrole aldehyde homologue, was found to be a major component, approximately 8.2 μg g -1 in the dry powder of L. edodes. Compound 1 showed cytotoxicity against SMMC-772 (IC50 15.8 μM) without any cytotoxic effect on LO2, a normal hepatic cell line; compounds 1 and 2 displayed weak immunosuppressive activities by inhibiting the proliferation of induced T cells; compound 3 showed inhibition activity on the proliferation of HaCaT cell line (IC50 25.4 μM) and weak antioxidant activity at a concentration of 50 μM.
More Related Videos
06:04Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
Published on: September 28, 2022
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Fungal Phylum Basidiomycota
Fungal Phylum Ascomycota
Fungal Group Zygomycota
CNS Stimulants: Psychedelic Agents
Bacterial Phylum Planctomycetes