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Invasive Candidiasis in Patients with Solid Tumors: A Single-Center Retrospective Study
1Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
International Journal of General Medicine
|June 19, 2023
Summary
Invasive candidiasis in solid tumor patients is a significant cause of mortality. Key risk factors for death include ICU stay, urinary catheter use, parenteral nutrition, renal failure, and neutrophil count, aiding early intervention for high-risk individuals.
Area of Science:
- Oncology
- Infectious Diseases
- Critical Care Medicine
Background:
- Invasive candidiasis (ICs) is a frequent cause of mortality in patients with solid tumors.
- Limited studies have detailed the clinical characteristics of ICs in this patient population.
Purpose of the Study:
- To retrospectively analyze the clinical characteristics, laboratory results, and risk factors for mortality in hospitalized patients with solid tumors and ICs.
- To identify prognostic factors associated with death in this cohort.
Main Methods:
- Retrospective review of clinical data and Candida specimen information from January 2016 to December 2020.
- Inclusion of 243 hospitalized patients diagnosed with solid tumors and ICs.
- Multivariate logistic regression analysis to determine prognostic factors for mortality.
Main Results:
- The most common Candida species were *Candida parapsilosis* (41.5%) and *Candida guilliermondii* (34.1%).
- Significant prognostic factors for mortality included length of ICU stay, urinary catheter use, total parenteral nutrition, renal failure, and neutrophil count.
- The average age of patients was 62.8 years, with a majority being male and having digestive system malignancies.
Conclusions:
- Length of ICU stay, urinary catheter, total parenteral nutrition, renal failure, and neutrophil count are key prognostic factors for mortality in solid tumor patients with ICs.
- Findings can guide early intervention strategies for high-risk patients, improving clinical outcomes.
