Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hyperbaric oxygen induced experimental epilepsy: the age factor.

C Masserini, E Rosina, F Morosini

Italian Journal of Neurological Sciences

|June 1, 1986

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of COMT polymorphisms on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.

Journal of affective disorders·2018

Same author

Gray matter differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.

Journal of affective disorders·2018

Same author

The role of genes and environment on brain alterations in Major Depressive Disorder: A review of twin studies: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.

Journal of affective disorders·2017

Same author

Quetiapine-Induced Hypomania and its Association with Quetiapine/Norquetiapine Plasma Concentrations: A Case Series of Bipolar Type 2 Patients.

Drug safety - case reports·2017

Same author

Metabolic alterations in generalised anxiety disorder: a review of proton magnetic resonance spectroscopic studies.

Epidemiology and psychiatric sciences·2017

Same author

Detection of venous gas emboli after repetitive breath-hold dives: case report.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2017

Same journal

Attualità in neurochirurgia : Edited by P. Paoletti, R. Kneich, R. Urcioli, C. Spairani Atti del XXXV Congresso Nazionale della Società Italiana di Neurochirurgia, September 1986. Mondadori Editore, 829 pages.

Italian journal of neurological sciences·2016

Same journal

24th Annual Meeting of the Italian Neuropathological Association : May 26-27-28, 1988 Napoli, Castel dell'Ovo.

Italian journal of neurological sciences·2016

Same journal

[Not Available].

Italian journal of neurological sciences·2016

Same journal

[Not Available].

Italian journal of neurological sciences·2016

Same journal

Pathogenesis and surgical treatment of neurovascular primary headaches.

Italian journal of neurological sciences·2016

Same journal

The complementary contribution of the rhinologist and the neurologist at the clinical study and treatment of the cluster headache.

Italian journal of neurological sciences·2016

See all related articles

Hyperbaric oxygen and pentylenetetrazole were used to induce experimental epilepsy in mice. Hyperbaric oxygen showed age-dependent effects on convulsion latency, unlike pentylenetetrazole.

Area of Science:

Neuroscience
Pharmacology
Epilepsy Research

Background:

Experimental epilepsy models are crucial for understanding seizure mechanisms.
Age-related changes in brain function are not fully understood.
Investigating convulsive agents aids in characterizing neurological processes.

Purpose of the Study:

To compare the efficacy of hyperbaric oxygen and pentylenetetrazole in inducing experimental epilepsy.
To investigate the age-dependent effects of these methods on seizure induction.
To evaluate their utility in studying cerebral maturation and aging.

Main Methods:

Male Swiss albino mice of varying ages were subjected to hyperbaric oxygen exposure.
Pentylenetetrazole (PTZ) treatment was administered to different age groups of mice.

Related Experiment Videos

Convulsion latency times were recorded and analyzed across age cohorts.

Main Results:

Hyperbaric oxygen induced age-dependent convulsions, with younger mice exhibiting longer latency periods but increasing sensitivity with age.
Pentylenetetrazole induced convulsions similarly across most age groups, excluding the youngest.
A progressive increase in sensitivity to hyperbaric oxygen-induced seizures was observed with advancing age.

Conclusions:

Hyperbaric oxygen serves as a valuable model for studying age-dependent experimental epilepsy.
The findings suggest distinct mechanisms underlying hyperbaric oxygen and pentylenetetrazole-induced seizures.
This research offers insights into neurochemistry and membrane alterations during brain maturation and aging.