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Aprocitentan: A new development of resistant hypertension
Yao Yao1,2, Bin Fan2, Bin Yang1
1Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Resistant hypertension is a growing concern with limited treatment options. Aprocitentan, an oral dual endothelin receptor antagonist, shows promise in phase 3 trials for managing this condition.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Drug Development
Background:
- Resistant hypertension (RH) prevalence is increasing due to lower blood pressure treatment thresholds.
- Existing antihypertensive medications have limitations in managing RH.
- There is a significant unmet need for novel RH therapeutics.
Purpose of the Study:
- To evaluate the efficacy and safety of aprocitentan for treating resistant hypertension.
- To investigate aprocitentan as a novel therapeutic agent targeting the endothelin system.
Main Methods:
- Aprocitentan is an orally active dual endothelin receptor antagonist (ERA).
- It inhibits endothelin-1 (ET-1) binding to both ETA and ETB receptors.
- Clinical development has progressed to phase 3 trials.
Main Results:
- Preliminary results from phase 3 trials are promising.
- Aprocitentan demonstrates potential as an effective treatment for RH.
Conclusions:
- Aprocitentan represents a potential new therapeutic option for patients with resistant hypertension.
- Further clinical data will confirm its role in managing this complex condition.
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