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The role of alternative splicing in lung cancer

Xuelian Ning1, Zitong Fu1, Jing Zhang2

  • 1Department of Pathology, Harbin Medical University, No.157 Baojian Road, Nangang District, Harbin, 150081, China.

Cancer Chemotherapy and Pharmacology
|June 19, 2023
PubMed

Insights

Aberrant alternative splicing (AS) is a fundamental cause of lung cancer, driving its development and progression. Understanding AS offers potential for novel diagnostic biomarkers and therapeutic strategies for lung cancer eradication.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Aberrant alternative splicing (AS) events are common in lung cancer.
  • These events stem from gene AS, altered splicing factors, or modified regulatory mechanisms.
  • Dysregulation of alternative RNA splicing is a root cause of lung cancer.

Purpose of the Study:

  • To review the critical role of AS in lung cancer.
  • To highlight AS's involvement in cancer development, progression, invasion, metastasis, angiogenesis, and drug resistance.
  • To emphasize AS's potential as diagnostic and prognostic biomarkers and its therapeutic applications.

Main Methods:

  • Literature review of alternative splicing in lung cancer.
  • Synthesis of current research on AS mechanisms and implications.
  • Analysis of AS isoforms in diagnosis, prognosis, and treatment.

Main Results:

  • AS plays a pivotal role in multiple stages of lung cancer, including development, invasion, and metastasis.
  • AS significantly influences angiogenesis and drug resistance in lung cancer.
  • AS isoforms show promise as biomarkers for lung cancer prognosis and diagnosis.

Conclusions:

  • Understanding alternative splicing is crucial for comprehending lung cancer.
  • AS isoforms represent potential therapeutic targets and diagnostic/prognostic tools.
  • Further research into AS may lead to effective lung cancer eradication strategies.
Keywords:
Alternative splicingDiagnosisLung cancerPrognosisTreatment

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