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Structural connectome alterations in anxious dogs: a DTI-based study.

Qinyuan Chen1, Yangfeng Xu2,3, Emma Christiaen4

  • 1Ghent Experimental Psychiatry (GHEP) Lab, Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. qinyuan.chen@ugent.be.

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Summary
This summary is machine-generated.

Anxious dogs exhibit altered brain network structures, specifically in posterior brain regions. This study reveals disrupted brain connectomes underlying anxiety disorders in canines.

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Area of Science:

  • Neuroscience
  • Veterinary Medicine
  • Behavioral Science

Background:

  • Domesticated dogs exhibit dysfunctional anxiety and fear behaviors, mirroring human psychopathology.
  • Understanding the neural basis of canine anxiety disorders is crucial due to shared similarities with humans.

Purpose of the Study:

  • To investigate the structural brain network differences in anxious dogs compared to healthy controls.
  • To identify specific brain regions and network properties associated with canine anxiety.

Main Methods:

  • Utilized diffusion tensor imaging (DTI) and graph theory to analyze brain structural connectivity.
  • Assessed anxiety levels using the validated Canine Behavioral Assessment & Research Questionnaire (C-BARQ).

Main Results:

  • Anxious dogs displayed significantly decreased global efficiency and clustering coefficient, alongside increased small-worldness.
  • Key differences in nodal parameters were observed in posterior brain regions, including the occipital lobe, hippocampus, and cerebellum.
  • Cerebellar connectivity negatively correlated with excitability traits in anxious dogs.

Conclusions:

  • Canine anxiety disorders are associated with a disrupted brain structural connectome.
  • Findings provide insights into the neurobiological mechanisms of anxiety-related disorders in dogs.
  • This research may inform future diagnostic and therapeutic strategies for canine anxiety.